Team:MIT/ResultsOverview

From 2012.igem.org

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The MIT iGEM team set out to bring aspects from the fields of DNA computing and synthetic biology together. Over the past few months we have:
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The MIT iGEM team set out to bring aspects from the fields of DNA computing and synthetic biology together. We tacked a project to build upon an existing <i>in vivo</i> method of nucleic acid computation, designing new components and extending strand displacement to <i>in vivo</i> applications. Over the past few months we have:
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* established the viability of RNA as an alternative processing medium to DNA
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<ul>
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* demonstrated RNA strand displacement in vivo
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<li> established the viability of RNA as an alternative processing medium to DNA
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* designed, modeled and tested a DNA-based NOT gate
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<li> demonstrated RNA strand displacement <i>in vivo</i>
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* designed, modeled and tested a modular mRNA sensor, along with an inverting sensor
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<li> designed, modeled, and tested a DNA-based NOT gate, compatible with strand displacement circuits
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* designed, modeled and tested various forms of regulating gene expression at the RNA level using
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<li> designed, modeled, and tested a modular mRNA sensor along with an inverting sensor, both compatible with strand displacement circuits
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** miRNA-induced RNAi knockdown
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<li> designed, modeled, and tested various forms of regulating gene expression at the RNA level, compatible with strand displacement circuits, using
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** Decoy & TuD mediated double-repression systems
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<ul>
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** self-cleaving Hammerhead ribozymes
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<li> miRNA-induced RNAi knockdown
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<li> Decoy & TuD mediated double-repression systems
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* characterized various new MammoBlock parts for transcribing short pieces of RNA in mammalian cells,
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<li> self-cleaving Hammerhead ribozymes
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</ul>
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<li> characterized various new MammoBlock parts for transcribing short pieces of RNA in mammalian cells
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</ul>
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Revision as of 02:10, 4 October 2012

DEPRECATED. DO NOT USE OR EDIT. If a page uses this template, relink with MIT-results2.

The MIT iGEM team set out to bring aspects from the fields of DNA computing and synthetic biology together. We tacked a project to build upon an existing in vivo method of nucleic acid computation, designing new components and extending strand displacement to in vivo applications. Over the past few months we have:
  • established the viability of RNA as an alternative processing medium to DNA
  • demonstrated RNA strand displacement in vivo
  • designed, modeled, and tested a DNA-based NOT gate, compatible with strand displacement circuits
  • designed, modeled, and tested a modular mRNA sensor along with an inverting sensor, both compatible with strand displacement circuits
  • designed, modeled, and tested various forms of regulating gene expression at the RNA level, compatible with strand displacement circuits, using
    • miRNA-induced RNAi knockdown
    • Decoy & TuD mediated double-repression systems
    • self-cleaving Hammerhead ribozymes
  • characterized various new MammoBlock parts for transcribing short pieces of RNA in mammalian cells

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