Team:Dundee
From 2012.igem.org
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<center><h2><em>C.Diff</em> Lysis</h2></center> | <center><h2><em>C.Diff</em> Lysis</h2></center> | ||
- | Recent research <a href="">[n]</a> investigating <em>C. diff.</em> cell disruption identified a bacteriophage ΦCD27 which encodes an endolysin that can effectively lyse <em>C. diff.</em> and which can be expressed within <em>E.coli</em>. It is the team's intention to create <em>E.coli</em> cells with capability to express ΦCD27 endolysin which will be delivered via a secretion system that permits transference of the endolysin through penetrative cell wall contact. The team plan to introduce the ΦCD27 endolysin to the <em>C. diff.</em> cells within the intestinal tract via the creation of a type VI secretion system <a href="">[n]</a> which will be expressed within the <em>E. coli</em> cells. This delivery system was chosen to improve effectivity of the endolysin by enabling cell wall penetration prior to the endolysin delivery. | + | Recent research <a href="https://2012.igem.org/Team:Dundee/References">[n]</a> investigating <em>C. diff.</em> cell disruption identified a bacteriophage ΦCD27 which encodes an endolysin that can effectively lyse <em>C. diff.</em> and which can be expressed within <em>E.coli</em>. It is the team's intention to create <em>E.coli</em> cells with capability to express ΦCD27 endolysin which will be delivered via a secretion system that permits transference of the endolysin through penetrative cell wall contact. The team plan to introduce the ΦCD27 endolysin to the <em>C. diff.</em> cells within the intestinal tract via the creation of a type VI secretion system <a href="https://2012.igem.org/Team:Dundee/References">[n]</a> which will be expressed within the <em>E. coli</em> cells. This delivery system was chosen to improve effectivity of the endolysin by enabling cell wall penetration prior to the endolysin delivery. |
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Revision as of 12:28, 5 July 2012