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| - | <h3>Tissues by Design</h3>
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| - | <p>Our project focuses on tissue self-construction to achieve specific patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators) with genetic circuits. To accomplish this, we focused on three components: cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global patternings.</p>
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| - | <p><img src="https://static.igem.org/mediawiki/2011/5/51/Simulation.jpg" style="max-width:800px; margin-right:10px;"/></p></br>
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| - | <p>Above is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p>
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| - | <p>Specifically, for cell-cell signaling, we developed a modular juxtacrine platform, using Notch and Delta proteins. For intracellular information processing circuits, as a proof of concept, we build a 2-input AND gate. For cell-cell adhesion, the final output of our system, we used cadherin.
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| - | Below is an animation depicting our project components. The cell-cell signaling of Notch-Delta interaction leads to the cleavage of the Notch intracellular domain, which enters the nucleus and after logic processing, expresses cadherins, which cause cells to adhere to similarly expressing cells.
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| - | <div align="center"><iframe width="400" height="300" src="http://www.youtube.com/embed/rGOB0gMxf_8" frameborder="0" allowfullscreen></iframe></div>
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| - | We developed software tools to model the behavior of our system. Below is a sample of a simulation of cells with genetic circuits and how they differentiate.
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| - | <div align="center"><iframe width="400" height="300" src="http://www.youtube.com/embed/dbz4VegsJOw?rel=0&hd=1" frameborder="0" allowfullscreen></iframe>
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| - | <h3>Sponsors</h3>
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| - | <ul>
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| - | <li><a href="http://www.bbn.com/"><img src='https://static.igem.org/mediawiki/2011/0/03/Mit-bbn.jpg' /></a></li>
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| - | <li><a href="http://www.geneious.com"><img src='https://static.igem.org/mediawiki/2011/6/65/Mit-geneious.jpg' /></a></li>
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| - | <li><a href="http://www.genewiz.com"><img src='https://static.igem.org/mediawiki/2011/3/33/Mit-genewiz.jpg' /></a></li>
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| - | <li><a href="http://www.neb.com"><img src='https://static.igem.org/mediawiki/2011/4/4d/Mit-neb.jpg' /></a></li>
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| - | <li><a href="http://www.embitec.com"><img src='https://static.igem.org/mediawiki/2011/7/75/Mit-embitec.jpg' style="width:175px" /></a></li>
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| - | <li><a href="http://ebics.net"><img src='https://static.igem.org/mediawiki/igem.org/0/0d/EBICS_logo.JPG' style="width:175px"></a></li>
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| - | <li><a href="http://ginkgobioworks.com/"><img src='http://ginkgobioworks.com/images/ginkgobioworks_logo.png' style="width:175px; "></a></li>
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| - | <li><a href="https://2011.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></li>
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| - | <h3>Gold Sponsors</h3>
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| - | <li><a href="http://www.emdchemicals.com"><img src='https://static.igem.org/mediawiki/2011/e/ee/Gold_emdmillipore.jpg' /></a></li>
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| - | </ul>
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| - | <h3>MIT Departments</h3>
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| - | <li><a href="http://www.csail.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/9/99/Mit-csail.jpg' /></a></li>
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| - | <li><a href="http://www.eecs.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/2/22/Mit-eecs.jpg' /></a></li>
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| - | <li><a href="http://web.mit.edu/be/"><img src='https://static.igem.org/mediawiki/2011/a/a7/Mit-be.jpg' /></a></li>
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| - | <li><a href="http://web.mit.edu/biology/www/"><img src='https://static.igem.org/mediawiki/2011/b/bf/Mitbiologo.jpg' /></a></li>
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