Team:Bonn

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Latest revision as of 00:30, 27 September 2012

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iGEM Team Bonn 2012

Fusion protein design has always been time- and design-intensive, to say the least. We are developing and characterizing a fusion construct containing a light sensitive domain, providing easy coupling and light activation of proteins of interest to investigators, thus developing a system to modify protein activity on protein-level just by using blue light.

Using the LOV (Light, Oxygen, Voltage) domain commonly found in plants, where it enables light-directed growth, we are establishing guidelines for coupling many interesting proteins to the LOV domain, which allows control of protein activity through blue wavelength light.

Designing our activity modifying structure at protein level allows quick response times (2.2 microseconds activation time, 85 seconds de- activation time). A device of that kind could be of great importance as a tool for disinfection on a laboratory scale or mutant selection via blue light. Further potential applications of our LOV fusion system might include bioreactor regulation or site-specific drug activation.

To visit our website at University of Bonn click [http://igem12.uni-bonn.de/en/ HERE].

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-<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+{{Template:Team:Bonn}}
+__NOTOC__
+<!--- The Mission, Experiments --->
+{| style="color:#5e92d2;background-color:#ffffff;" cellpadding="5" cellspacing="1" border="0" bordercolor="#fff" width="100%" align="left"
+!align="center"|[[Team:Bonn|<span style="color:#005186;">Home]]
+!align="center"|[[Team:Bonn/Team|<span style="color:#4f8dde;">Team]]
+!align="center"|[[Team:Bonn/Project|<span style="color:#4f8dde;">Project]]
+!align="center"|[[Team:Bonn/Activities|<span style="color:#4f8dde;">Other Activities]]
+!align="center"|[[Team:Bonn/Parts|<span style="color:#4f8dde;">Parts Submitted to the Registry]]
+!align="center"|[[Team:Bonn/Notebook|<span style="color:#4f8dde;">Notebook]]
+!align="center"|[[Team:Bonn/Safety|<span style="color:#4f8dde;">Safety]]
+!align="center"|[[Team:Bonn/Attributions|<span style="color:#4f8dde;">Attributions]]
+!align="center"|[[Team:Bonn/Sponsors|<span style="color:#4f8dde;">Sponsors]]
+|}
+{|align="center"
+|[[Image:dna-separation-bar.png|960px|no frame|link=]]
+|}
-<html>
+<div style="float:right;">
-<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
+[[Image:Bonn_lovlogo.png|200px]]
-<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
+<br/><br/><br/><br/>
-This is a template page. READ THESE INSTRUCTIONS.
+[[Image:Bonn_team.png|thumb|iGEM Team Bonn 2012]]
 </div>
-<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
-You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
-</div>
-<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
-You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace.
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-</div>
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-<!-- *** End of the alert box *** -->
+Fusion protein design has always been time- and design-intensive, to say the least.
+We are developing and characterizing a fusion construct containing a light sensitive domain,
+providing easy coupling and light activation of proteins of interest to investigators, thus
+developing a system to modify protein activity on protein-level just by using blue light.
+Using the LOV (Light, Oxygen, Voltage) domain commonly found in plants, where it enables light-directed growth, we are establishing guidelines for coupling many interesting proteins to the LOV domain, which allows control of protein activity through blue wavelength light.
-{|align="justify"
+Designing our activity modifying structure at protein level allows quick response times (2.2 microseconds activation time, 85 seconds de-
-|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
+activation time). A device of that kind could be of great importance as a tool for disinfection on a laboratory scale or mutant selection via blue light. Further potential applications of our LOV fusion system might include bioreactor regulation or site-specific drug activation.
-|[[Image:Bonn_logo.png|200px|right|frame]]
-|-
-|
-''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
-|[[Image:Bonn_team.png|right|frame|Your team picture]]
-|-
-|
-|align="center"|[[Team:Bonn | Team Bonn]]
-|}
-<!--- The Mission, Experiments --->
-{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
-!align="center"|[[Team:Bonn|Home]]
+'''To visit our website at University of Bonn click [http://igem12.uni-bonn.de/en/ HERE].'''
-!align="center"|[[Team:Bonn/Team|Team]]
-!align="center"|[https://igem.org/Team.cgi?year=2012&team_name=Bonn Official Team Profile]
-!align="center"|[[Team:Bonn/Project|Project]]
-!align="center"|[[Team:Bonn/Parts|Parts Submitted to the Registry]]
-!align="center"|[[Team:Bonn/Modeling|Modeling]]
-!align="center"|[[Team:Bonn/Notebook|Notebook]]
-!align="center"|[[Team:Bonn/Safety|Safety]]
-!align="center"|[[Team:Bonn/Attributions|Attributions]]
-|}