Team:Dundee/Modelling5

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<li class='has-sub'><a href='https://2012.igem.org/Team:Dundee/Wet Lab'><span>Wet Lab</span></a>
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<li class='has-sub'><a href='https://2012.igem.org/Team:Dundee/Strategy'><span>Wet Lab</span></a>
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               <li><a href='https://2012.igem.org/Team:Dundee/Strategy'><span>Strategy</span></a></li>
               <li><a href='https://2012.igem.org/Team:Dundee/Strategy'><span>Strategy</span></a></li>
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      <h2><img src="https://static.igem.org/mediawiki/2012/4/49/Overview_header.png"></h2>
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<h2><img src="https://static.igem.org/mediawiki/2012/8/86/Movies_header.png
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These movies animate some of our results: see sections  on the right for details.  Click on each  link to play (files are .mov) <br><br> <hr style="height: 1px;"/>
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<center><img src="https://static.igem.org/mediawiki/2012/7/7c/Bulkflow_header.png"><br><br>
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<h4>Gut Section</h4>
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<h4><a href="https://static.igem.org/mediawiki/2012/0/00/Flowinsect.mov">Bulk Flow in Gut Section</a> &nbsp;&nbsp;
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<h4><a href="https://static.igem.org/mediawiki/2012/7/73/Part1_s.mov">Particle Flow in Gut Section</a> </h4><br>
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<h4>The  Colon</h4>
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<h4><a href="https://static.igem.org/mediawiki/2012/f/f8/Colon_flow.mov">Bulk Flow in the Colon</a> &nbsp;&nbsp;
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<h4><a href="https://static.igem.org/mediawiki/2012/e/e7/Part2_s.mov">Particle Flow in Colon</a> </h4><br><br>
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<center><img src="https://static.igem.org/mediawiki/2012/b/b8/Modellingbetween_header.png"><br><br>
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<h4>Interactions  in a Gut Section</h4>
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<h4><a href="https://static.igem.org/mediawiki/2012/3/3b/E.coli_sect.mov">E.coli colonising the gut killing C.difficile</a>&nbsp;&nbsp;
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<h4><a href="https://static.igem.org/mediawiki/2012/1/18/Cdiff_sect.mov">C.difficile killed by the modified E.coli</a></h4><br>
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<h4>Interactions  in the Colon</h4>
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<h4><a href="https://static.igem.org/mediawiki/2012/e/ee/Figure_9_-_e.coli.mov">E.coli colonising the gut killing C.difficile</a> &nbsp;&nbsp;
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<h4><a href="https://static.igem.org/mediawiki/2012/3/3e/C.diff_gut.mov">C.difficile killed by the modified E.coli </a> </h4><br><br>
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                The problem addressed in this project is characterised by processes occurring  over a vast range of spatial and temporal scales: from the protein structure of the T6SS to  large-scale effects in the colon.  This range of scales presents a chain of biological questions: can we engineer an <i>E.coli</i> that produces enough endolysin to kill <i>C. difficile</i>? What are the factors that could lead to success and failure of an <i>E. coli</i> therapy? What if processes are stochastic? Could our engineered <i>E. coli</i> be an efficient solution in realistic conditions? The mathematical modelling component of this project attempts to address these questions by both underpinning the lab work and extending it beyond what is capable on the bench. Clicking on the tabs to the right and linking to the <a href='https://2012.igem.org/Team:Dundee/Software'><span>Software Page </span></a>,  will reveal the  variety of modelling techniques used  -  from ODE and PDE models to our bespoke CellSim cellular automata. Our results obtained so far are summarised there. The work continues…<br><br>
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<center><img src="https://static.igem.org/mediawiki/2012/b/b5/Dundeemovies11.png"><br>
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<a href="https://static.igem.org/mediawiki/2012/e/ee/Figure_9_-_e.coli.mov">
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<h4><a href="https://static.igem.org/mediawiki/igem.org/3/32/Dundee12cellsimanimsmall.gif"> CellSim animation of cell interactions in flow (.gif)</a></center>  </h4><br>
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                    <img src="https://static.igem.org/mediawiki/2012/e/ee/Figure_9_-_e.coli.mov" width="400px" alt="E.coli" />
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                <img src="https://static.igem.org/mediawiki/2012/3/31/Mathspic2.jpg">
 
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             <a href="https://2012.igem.org/Team:Dundee/Modelling5"><img src="https://static.igem.org/mediawiki/2012/9/99/Movies_button1.jpg"></a>
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Latest revision as of 23:49, 26 September 2012