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Team:Trieste/parts/9
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<p> LL-37 is a 37-residue, amphipathic, helical human peptide that has been shown to exhibit a broad spectrum of antimicrobial activity. </br> | <p> LL-37 is a 37-residue, amphipathic, helical human peptide that has been shown to exhibit a broad spectrum of antimicrobial activity. </br> | ||
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| + | The antimicrobial peptides (AMPs) form an important part of innate immunity, protecting the organism from infection by directly killing invading bacteria. Since pathogenic microorganism show an increasing tendency to be immune against common antibiotics, AMPs carry remarkable pharmaceutical promise as next-generation antibiotics. </br> | ||
The exact mechanism by which AMPs kill microorganisms is still under debate.</br> | The exact mechanism by which AMPs kill microorganisms is still under debate.</br> | ||
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<h2>Assembly</h2> | <h2>Assembly</h2> | ||
Revision as of 14:38, 26 September 2012
BBa_K875009
More
Description
LL-37 is a 37-residue, amphipathic, helical human peptide that has been shown to exhibit a broad spectrum of antimicrobial activity. The antimicrobial peptides (AMPs) form an important part of innate immunity, protecting the organism from infection by directly killing invading bacteria. Since pathogenic microorganism show an increasing tendency to be immune against common antibiotics, AMPs carry remarkable pharmaceutical promise as next-generation antibiotics. The exact mechanism by which AMPs kill microorganisms is still under debate. It has been found to have additional defensive roles such as regulating the inflammatory response and chemo-attracting cells of the adaptive immune system to wound or infection sites, binding and neutralizing LPS, and promoting re-epthelialization and wound closure.
Assembly
Obtained by synthesis
Looking forward
At the beginning, our idea was to use the LL 37 cathelicidin as a toxin, to kill the bacteria from inside. Unfortunately this approach was unsuccessfully as the LL 37 does not kill the bacteria. We thought to use the LL 37 in another way, combined with the T4 holin, (BBa_K112000) a small bacteriophage-encoded proteins that accumulate during the period of late-protein synthesis after infection and cause lysis of the host cell at a precise genetically programmed time. The rational of this construct is to create a synergic action were the holin creates the pores through which the LL 37 can reach his target.
Link to the Registry
