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Team:Trieste
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<strong>Background</strong></br>Recent studies have evidenced that having a beneficial and healthy | <strong>Background</strong></br>Recent studies have evidenced that having a beneficial and healthy | ||
intestinal microflora is very important for human health.</br> | intestinal microflora is very important for human health.</br> | ||
| - | <strong>Project</strong></br> Our | + | <strong>Project</strong></br> |
| + | </br> Our | ||
aim is to modify a bacteria normally found in human gut and | aim is to modify a bacteria normally found in human gut and | ||
create a safe, controllable and versatile molecular platform | create a safe, controllable and versatile molecular platform | ||
Revision as of 19:37, 23 September 2012
Our Project
Quick Links
The Team
WE PRESENT YOU THE JOLLY JOCARE
BackgroundRecent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Project Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules leading to a beneficial probiotic. For this purpose we have chosen the E. coli strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer.
ApplicationsThe safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.
