Team:Trieste/sandbox/home

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<div id="head">
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    <meta charset="UTF-8">
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    <title>Team iGEM 2012</title>
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    <script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.7.2/jquery.min.js" ></script>
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<div id="body">
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    <div id=header>
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<h3>let us introduce you...</h3>
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<h1>Project X</h1>
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<div id="logo"><img src="logo.png" alt="logo" width="100"/></div>
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    </div>
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    <div id=menu>
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<ul>
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    <li class="active"><a href="home" >home</a></li>
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    <li><a href="team" >team</a></li>
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    <li><a href="project" >project</a></li>
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    <li><a href="data" >data</a></li>
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    <li><a href="parts" >parts</a></li>
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    <li><a href="notebook" >notebook</a></li>
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    <li><a href="safety" >safety</a></li>
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    <li><a href="outreach" >outreach</a></li>
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    <li><a href="extra" >extra</a></li>
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<a href="https://2012.igem.org" ><img src="https://static.igem.org/mediawiki/2012/a/ad/Logo_igem.png" alt="Logo iGEM"/></a>
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    <div id="container">
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    <h1><span class="light">Our</span> project</h1>
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<h2>A safe synthetic probiotic expression system for antibodies.</h2>
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<p>Noroviruses (NoV) are cause of epidemic outbreaks of gastrointestinal illness. Even if they are considered as a moderate threat – classified as category B pathogens by the National Institute of Allergy and Infectious diseases – the spreading speed of these pathogens is dramatic: rates of reported NoV outbreaks reach 21 million cases of acute gastroenteritis per year, 70.000 of those need hospitalization and 800 die. This is due to a rapid person-to-person transmission in semi-closed places like hospital, school and public transports. Moreover it seems that it is really difficult to develop an immunological memory against NoV that avoids further illness.
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                </p>
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Our project aims to build a probiotic bacteria that helps the immune system to fight this pathogenic agent. First of all we had to choose a suitable bacterial strain for the gut environment that can easily be manipulated. Than we had to face an important issue: safety. For this purpose we designed a robust gene guard system regulated by a novel inducible switch and by an human antimicrobial peptide that can destroy, in any moment, the bacteria and avoid the transgene horizontal exchange.
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Finally we will provide to our bacteria a weapon able to capture and inactivate our target thanks to a synthetic minibody fused to a protein membrane. This feature can be slightly modified to target any other pathogenic agent with enteric tropism.
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<h1 class="green"><span class="light">Our</span> team</h1>
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<div class="inner_column">
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                    <img src="https://static.igem.org/mediawiki/2012/b/b0/Team_trieste.jpg" alt="Team trieste 2012" />
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    <h2><span class="light">Contact</span> us</h2>
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                    <p>
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    For more information write to:
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                    <a href="mailto:igem2012@gmail.com" class="button">igem2012@gmail.com</a>
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    <h1 class="red"><span class="light">Latest</span> news</h1>
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    <h2>Modeling meeting</h2>
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    We've met with our modeling advisor, and we now have a theoretical model that we can try to fit some experimental data on!
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    <h1>Our Partners</h1>
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    <img src="https://static.igem.org/mediawiki/2012/2/28/Units.jpg" alt="Università di Trieste" />
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    <img src="https://static.igem.org/mediawiki/2012/2/21/Icgeb.jpg" alt="ICGEB" />
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    <img src="https://static.igem.org/mediawiki/2012/0/08/Illy.jpg" alt="Illy Caffè" />
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    <img src="https://static.igem.org/mediawiki/2012/f/f5/Fcrt.jpg" alt="Fondazione cassa di Risparmio di Trieste" />
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Latest revision as of 18:42, 7 September 2012

Retrieved from "http://2012.igem.org/Team:Trieste/sandbox/home"