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| - | <script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.7.2/jquery.min.js" ></script>
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| - | <script type="text/javascript" src='/Team:Trieste/static/page_boot.js?action=raw&ctype=text/javascript'></script>
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| - | <div id="head">
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| - | <meta charset="UTF-8">
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| - | <title>Team iGEM 2012</title>
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| - | <link rel="stylesheet" href='/Team:Trieste/static/main.css?action=raw&ctype=text/css' type="text/css" />
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| - | </div>
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| - | <div id="body">
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| - | <div id=header>
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| - | <h3>let us introduce you...</h3>
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| - | <h1>Project X</h1>
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| - | <div id="logo"><img src="logo.png" alt="logo" width="100"/></div>
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| - | </div>
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| - | <div id=menu>
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| - | <ul>
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| - | <li><a href="home" >home</a></li>
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| - | <li><a href="team" >team</a></li>
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| - | <li><a href="project" >project</a></li>
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| - | <li><a href="data" >data</a></li>
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| - | <li><a href="parts" >parts</a></li>
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| - | <li><a href="notebook" >notebook</a></li>
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| - | <li><a href="safety" >safety</a></li>
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| - | <li><a href="outreach" >outreach</a></li>
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| - | <li><a href="extra" >extra</a></li>
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| - | </ul>
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| - | <a href="https://2012.igem.org" ><img src="https://static.igem.org/mediawiki/2012/a/ad/Logo_igem.png" alt="Logo iGEM"/></a>
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| - | <div id="container">
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| - | <div id="content">
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| - | <div class="column" id="col1">
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| - | <h1>Our project</h1>
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| - | <div class="inner_column">
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| - | <h2>A safe synthetic probiotic expression system for antibodies.</h2>
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| - | <p>Noroviruses (NoV) are cause of epidemic outbreaks of gastrointestinal illness. Even if they are considered as a moderate threat – classified as category B pathogens by the National Institute of Allergy and Infectious diseases<sup><a href="#footnote1">[1]</a></sup> – the spreading speed of these pathogens is dramatic: rates of reported NoV outbreaks reach 21 million cases of acute gastroenteritis per year, 70.000 of those need hospitalization and 800 die<sup><a href="#footnote2">[2]</a></sup>. This is due to a rapid person-to-person transmission in semi-closed places like hospital, school and public transports. Moreover it seems that it is really difficult to develop an immunological memory against NoV that avoids further illness.
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| - | <p>
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| - | Our project aims to build a probiotic bacteria that helps the immune system to fight this pathogenic agent. First of all we had to choose a suitable bacterial strain for the gut environment that can easily be manipulated. Than we had to face an important issue: safety. For this purpose we designed a robust gene guard system regulated by a novel inducible switch and by an human antimicrobial peptide that can destroy, in any moment, the bacteria and avoid the transgene horizontal exchange.
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| - | </p>
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| - | Finally we will provide to our bacteria a weapon able to capture and inactivate our target thanks to a synthetic minibody fused to a protein membrane. This feature can be slightly modified to target any other pathogenic agent with enteric tropism.
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| - | </p>
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| - | <hr />
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| - | <p>
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| - | <span id="footnote1">[1] <a href="http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx">http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx</a></span><br />
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| - | <span id="footnote2">[2] <a href="http://www.cdc.gov/norovirus/trends-outbreaks.html">http://www.cdc.gov/norovirus/trends-outbreaks.html</a></span>
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| - | </p>
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| - | </div>
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| - | </div>
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| - | <div class="column" id="col3">
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| - | <h1 class="green">Our team</h1>
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| - | <div class="inner_column">
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| - | <p>
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| - | For more information write to:
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| - | </p>
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| - | <span class="button">igem2012@gmail.com</span>
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| - | </div>
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| - | </div>
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| - | <div class="column" id="col2">
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| - | <h1 class="red">Latest news</h1>
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| - | <div class="inner_column">
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| - | <h2>Modeling meeting</h2>
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| - | <p>
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| - | We've met with our modeling advisor, and we now have a theoretical model that we can try to fit some experimental data on!
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| - | </p>
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| - | </div>
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| - | </div>
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| - | </div>
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| - | <div id="footer">
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| - | <h1>Our Partners</h1>
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| - | <img src="https://static.igem.org/mediawiki/2012/2/28/Units.jpg" alt="Università di Trieste" />
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| - | <img src="https://static.igem.org/mediawiki/2012/2/21/Icgeb.jpg" alt="ICGEB" />
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| - | <img src="https://static.igem.org/mediawiki/2012/0/08/Illy.jpg" alt="Illy Caffè" />
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| - | <img src="https://static.igem.org/mediawiki/2012/f/f5/Fcrt.jpg" alt="Fondazione cassa di Risparmio di Trieste" />
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| - | </div>
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