Team:Trieste/sandbox/home

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<div id="head">
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    <title>Team iGEM 2012</title>
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</div>
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<div id="body">
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    <div id=header>
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<h3>let us introduce you...</h3>
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<h1>Project X</h1>
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<div id="logo"><img src="logo.png" alt="logo" width="100"/></div>
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    </div>
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    <div id=menu>
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<ul>
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    <li><a href="home" >home</a></li>
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    <li><a href="team" >team</a></li>
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    <li><a href="project" >project</a></li>
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    <li><a href="data" >data</a></li>
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    <li><a href="parts" >parts</a></li>
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    <li><a href="notebook" >notebook</a></li>
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    <li><a href="safety" >safety</a></li>
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    <li><a href="outreach" >outreach</a></li>
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    <li><a href="extra" >extra</a></li>
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<a href="https://2012.igem.org" ><img src="https://static.igem.org/mediawiki/2012/a/ad/Logo_igem.png" alt="Logo iGEM"/></a>
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    <h1>Our project</h1>
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<h2>A safe synthetic probiotic expression system for antibodies.</h2>
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<p>Noroviruses (NoV) are cause of epidemic outbreaks of gastrointestinal illness. Even if they are considered as a moderate threat – classified as category B pathogens by the National Institute of Allergy and Infectious diseases<sup><a href="#footnote1">[1]</a></sup> – the spreading speed of these pathogens is dramatic: rates of reported NoV outbreaks reach 21 million cases of acute gastroenteritis per year, 70.000 of those need hospitalization and 800 die<sup><a href="#footnote2">[2]</a></sup>. This is due to a rapid person-to-person transmission in semi-closed places like hospital, school and public transports. Moreover it seems that it is really difficult to develop an immunological memory against NoV that avoids further illness.
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Our project aims to build a probiotic bacteria that helps the immune system to fight this pathogenic agent. First of all we had to choose a suitable bacterial strain for the gut environment that can easily be manipulated. Than we had to face an important issue: safety. For this purpose we designed a robust gene guard system regulated by a novel inducible switch and by an human antimicrobial peptide that can destroy, in any moment, the bacteria and avoid the transgene horizontal exchange.
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Finally we will provide to our bacteria a weapon able to capture and inactivate our target thanks to a synthetic minibody fused to a protein membrane. This feature can be slightly modified to target any other pathogenic agent with enteric tropism.
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                <hr />
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                    <span id="footnote1">[1] <a href="http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx">http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx</a></span><br />
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                    <span id="footnote2">[2] <a href="http://www.cdc.gov/norovirus/trends-outbreaks.html">http://www.cdc.gov/norovirus/trends-outbreaks.html</a></span>
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                </p>
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</div>
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    <div class="column" id="col3">
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<h1>Our team</h1>
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<div class="inner_column">
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    <h1>Latest News</h1>
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    <h2>blahblah</h2>
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    If the current box is left-floating, and there are any left-floating boxes generated by elements earlier in the source document, then for each such earlier box, either the left outer edge of the current box must be to the right of the right outer edge of the earlier box, or its top must be lower than the bottom of the earlier box. Analogous rules hold for right-floating boxes.
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    The right outer edge of a left-floating box may not be to the right of the left outer edge of any right-floating box that is next to it. Analogous rules hold for right-floating elements.
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    <h1>Our Partners</h1>
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    <img src="https://static.igem.org/mediawiki/2012/2/28/Units.jpg" alt="Università di Trieste" />
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    <img src="https://static.igem.org/mediawiki/2012/2/21/Icgeb.jpg" alt="ICGEB" />
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    <img src="https://static.igem.org/mediawiki/2012/0/08/Illy.jpg" alt="Illy Caffè" />
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    <img src="https://static.igem.org/mediawiki/2012/f/f5/Fcrt.jpg" alt="Fondazione cassa di Risparmio di Trieste" />
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Latest revision as of 18:42, 7 September 2012

Retrieved from "http://2012.igem.org/Team:Trieste/sandbox/home"