Revision as of 06:45, 15 July 2012 by CubicStone (Talk | contribs)
Left, right, the E. CoLIFE

An SSRs System Based Toggle Switch and More




‘Life’ is too big a word, especially when we are talking about synthetic biology, but we still find it interesting, in our life, when everyone meets alternatives and makes his decisions, that colorful behaviors and lifestyles just differentiate from small left-or-right choices, and that widely-differed ones make up a well-operated society. This year our study will be concentrated on controllable choice-making E. Coli, with left-or-right directions of gene expression to be determined, thus to realize the life-like differentiation and dedifferentiation, and synthesized function of the cell ‘teamwork’. That’s the idea why we named our project after ‘E. CoLIFE’.


虽然我们在谈合成生物学,可是还是一不小心扯到“人生”这个大命题。偶尔去想,世界的多元竟然是由每个人每一次“向左走、向右走”的小决定来实现,而这样的多元相融又能够和谐运行,实在是一件有趣的事。因而我们将目光聚焦于“能做决定”的大肠杆菌,通过控制一组基因向左或向右的表达,努力去模拟以实现仿生的分化和去分化,并创意地构造功能可控的基因“团队”。 我们称之为“细菌人生”。以上。


The season 2012 will witness a great leap further for Team Tsinghua-A. In our second year of this game, we iGEMers focus on a special kind of enzymes named site-specific recombinases (SSRs), and will hopefully achieve the goal of the construction of a symmetric toggle switch to ‘make cell choices’, with problems on close loop control and robustness to be worked out. Beyond the basic switch we are still more ambitious, eagerly to design, and to some extent realize a programmable E. Coli gene sequence, with the combinations of multifunctional AND/OR switch segments, the idea of which comes from FPGA, a programmable gate array widely used in electronics development.



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