Team:TU-Delft/Modeling

From 2012.igem.org

Revision as of 09:19, 7 September 2012 by Lmohremaruthi (Talk | contribs)

Menu


Modeling

Mathematical models are increasingly used to study certain aspects of signal transduction pathways, i.e. robustness against concentration variations [1], threshold properties and bistability [2] etc.

In an attempt to illustrate and understand the dynamics of our modified Saccharomyces cerevisiae (yeast) we created a complete mathematical model for the sequence of events when the hCG hormone binds to our modified receptor in the yeast (LH/CG receptor) and in the end starts an indigo production (click here for more information). Our model is based on the yeast pheromone pathway (click here for more information) [3].

The aim or goal of the model was to use it to analyze and understand where possible problems would occur in the lab and also to make some predictions, eg. estimates of how large concentrations of hCG is needed to, at least in theory, give an output signal, that is for indigo to be produced.