Team:TU-Delft/HP

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<h2>Snifferomyces - A solution for world problems?</h2><br>
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<p>This is a very complicated question. When we started the project, first was determined on which possible solutions we would perform study:
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<ul>
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<li>Tuberculosis Detection
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<li>Detection of explosives
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</ul>
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The tuberculosis detection was our main case study and a lot of wetlab work on this possible methyl nicotinate receptor has been done.
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The detection of explosives is a application we thought of was inspired by the K-9's detecting explosives. Reportings of sensing DNT by yeast strains (Venkat Radhika et al. (2007)) supported this.
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<br/>
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<h4>Is Snifferomyces the solution for tuberculosis detection?</h4>
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This question is approached on two different ways. A interview with Dr. Rene Lutter and a implementation study. For the implementation study we subdivided
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this question into several smaller, more specific questions.
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<ul>
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<li>What is tuberculosis?
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<li>What are the present diagnostic tools?
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<li>Why would a diagnostic tool based on our principle contribute?
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<li>What does the problem area look like?
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<li>What would be the possible drawbacks during R&D and usage?
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<h2>Snifferomyces - A Tuberculosis Screening Automaton</h2><br>
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</ul>
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<p> What is the use of technology, if it cannot contribute to improving human life? With this thought in mind, the TU Delft 2012 iGEM team, composed of students from the life sciences, bioinformatics, applied physics, aerospace, maritime, mechanical and chemical engineering disciplines decided to use the platform of synthetic biology, addressing a real challenge affecting millions of people .
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<h4>Is Snifferomyces the solution for explosive detection?</h4>
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In this case we didn't do a wetlab study but spoke to the <i>Royal Dutch Military Police</i>. The Royal Dutch Military Police are present
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Inspired by the sniffer rats trained to smell the presence of tuberculosis, the team decided to build an autonomous olfactory system to detect volatile compounds, by re-inventing man's oldest industrial microorganism, yeast, to provide for a non-invasive, rapid and cost-effective diagnosis system for tuberculosis.</p>
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at Schiphol to detect possible threats to the National Security. One part of their job is to be on the lookout for explosives. This is mainly
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done by K-9's, we asked their opinion about using micro organisms and GMO's as explosive detectors!
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<h3>What is Tuberculosis?</h3>
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<p>Tuberculosis is a bacterial infection. TB usually attacks the lungs, but can also attack other parts of the body, such as the brain, spine, or kidneys. TB bacteria can live in the body without making a person sick. This is called latent TB infection. People with latent TB infection do not feel sick, do not have TB symptoms, and cannot spread TB bacteria to others. Some people with latent TB infection go on to develop TB disease.
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<br/>In 2010, 8.8 million people were infected with TB and 1.4 million died from it. Over 95% of TB deaths occur in low -and middle- income countries.</p>
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<p>At the map below you can see the countries suffering from Tuberculosis. According to <a href="http://www.vaccinatiesopreis.nl">www.vaccinatiesopreis.nl</a> the dark green refers to many cases of TB, the light green to less and the white to a few cases.</p>
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<div style="position:relative; align:center; top:0; left:0;  width:580px; height:240px; border:0; margin:0 0 20px 0; padding:0; ">
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<a href="https://static.igem.org/mediawiki/igem.org/4/4a/TBmap.gif" rel="lightbox" title="Tuberculosismap">
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<img src="https://static.igem.org/mediawiki/igem.org/4/4a/TBmap.gif" name="kugroup" width="570"  border="0" id="kugroup" /></a></div>
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<h3>The problem</h3>
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<p>The problem of tuberculosis lies mainly in the less developed countries. There are the people who have no or limited access to hospitals with sufficient facilities. Standard TB diagnostic tools are expensive and need to be used in a lab setting, posing major barriers for diagnosing.
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<h3>Our ideal Solution</h3>
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<center><h3>Please click on the photo's to see the project</h3></center>
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<p>A cheap test that gives an reliable result, that can be taken by car to the people.</p>
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<h3>What would a test basis on our principle contribute</h3>
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<table id="tbtext">
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<h3>Six Ways to Diagnose Tuberculosis</h3>
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<p>There are six main diagnosis tools for TB. The problem is that there is not one of them that is very reliable and suitable for the frontline.</p>
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<body>
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    <ul>
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          <li>Tuberculin Skin Test (TST)
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          <li>Sputum Smear Microscopy (SSM)
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          <li>Polymerase Chain Reaction (PCR)
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<li>Blood Test for TB detection
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<li>Chest X-ray
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<li>Culture
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    </ul>
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</body>
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<h3>Example Mozambique</h3>
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Mozambique ranks the 19th among the 22 Tuberculosis High Burden Countries 2011.
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First some facts and figures about Mozambique according to the <a href="http://www.afro.who.int/en/mozambique/country-programmes/aids-tuberculosis-and-malaria/tuberculosis.html" target="_blank">WHO</a>
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<table id="tbtext">
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<th>Repeats</th>
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<th>Military Police</th>
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<th>Temperature</th>
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<th>Implementation Study</th>
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<th></th>
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<th>Interview with Doctor</th>
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<th>Duration</th>
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<td rowspan="3" id="tdunderline">5x</td>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HP/MP" target="_blank">  
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<td id="tdunderline">95</td>
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<img src="https://static.igem.org/mediawiki/igem.org/9/9a/Hond.jpg" height="130" width="189"/></a></td>
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<td id="tdunderline">Melting</td>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HP/Study" target="_blank">
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<td id="tdunderline">2:00</td>
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<img src="https://static.igem.org/mediawiki/igem.org/b/b2/HospitalILHAM.JPG" height="130" width="189"/></a></td>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HP/DocTalk" target="_blank">  
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<img src="https://static.igem.org/mediawiki/igem.org/d/d2/Stethoscope-2.png" height="130" width="189"/></a></td>
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<p>One of our team members, Isabelle, traveled to Mozambique in 2011, accompanied by a lung physician. The lack of the diagnostic capacity is very clear at the hospital of Ilha de Mocambique. The picture is taken in july 2011.</p><img src="https://static.igem.org/mediawiki/igem.org/b/b2/HospitalILHAM.JPG" height="330" width="600"/>
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<p>Ilha de Mocambique has a population of 14.000 people. </p>
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<h2>Human practice</h2>
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<p>Our team focused on several part of the category called human practise. We were in a very good
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collaboration with a MSc student in Educational studies named <a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/CollaborativeL" target="_blank">Amalia Ephrat</a>. During the brainstorm
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sessions the team helped her to observe collaborative learning activities.
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We are also part of a documentary called Lab-Life, which is filmed by <a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/Documentary" target="_blank">Frank Theys</a>. In this
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documentary he follows the daily life of the scientific research project of our team. For this
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documentary an embedded humanist, <a href="https://2012.igem.org/Team:TU-Delft/Ethics" target="_blank">Daan Schuurbiers</a> was partly involved with our p roject. His
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professional view on social sciences helped our team a lot.
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Furthermore, during the European jamboree TUDelft 2012 iGEM team will organize together with the Rathenau
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Institute a debate called Meeting of Young Minds. The subject of this debate will be the H5N1 virus
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and wether the research manuscript should have been published. This will be a very interesting
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debate with different experts, the team and of course the audience!
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Latest revision as of 01:16, 27 October 2012

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Human Practice


Snifferomyces - A solution for world problems?


This is a very complicated question. When we started the project, first was determined on which possible solutions we would perform study:

  • Tuberculosis Detection
  • Detection of explosives
The tuberculosis detection was our main case study and a lot of wetlab work on this possible methyl nicotinate receptor has been done. The detection of explosives is a application we thought of was inspired by the K-9's detecting explosives. Reportings of sensing DNT by yeast strains (Venkat Radhika et al. (2007)) supported this.

Is Snifferomyces the solution for tuberculosis detection?

This question is approached on two different ways. A interview with Dr. Rene Lutter and a implementation study. For the implementation study we subdivided this question into several smaller, more specific questions.
  • What is tuberculosis?
  • What are the present diagnostic tools?
  • Why would a diagnostic tool based on our principle contribute?
  • What does the problem area look like?
  • What would be the possible drawbacks during R&D and usage?

Is Snifferomyces the solution for explosive detection?

In this case we didn't do a wetlab study but spoke to the Royal Dutch Military Police. The Royal Dutch Military Police are present at Schiphol to detect possible threats to the National Security. One part of their job is to be on the lookout for explosives. This is mainly done by K-9's, we asked their opinion about using micro organisms and GMO's as explosive detectors!

Please click on the photo's to see the project

Military Police Implementation Study Interview with Doctor