Team:TU-Delft

From 2012.igem.org

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<li><a href="http://2012.igem.org/Team:TU-Delft/part2#A2"> Activation of the reporter by the native ligand alpha pheromone</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/part2#A2"> Activation of the reporter by the native ligand alpha pheromone</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/part1#P8"> Providing a platform to swap receptors, promoters and terminators more easy</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/part1#P8"> Providing a platform to swap receptors, promoters and terminators more easy</a></li>
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<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/StructuralModeling#youtube">Prediction of a ligand-binding niche with the niacin receptor</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Snifferometer">Prototype version of a yeast olfactory detector device: The Sniffer-o-meter</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Snifferometer">Prototype version of a yeast olfactory detector device: The Sniffer-o-meter</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Deterministic and stochastic simulations of pathway model</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Deterministic and stochastic simulations of pathway model</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Data fitting for deterministic pathway model</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Data fitting for deterministic pathway model</a></li>
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<li><a href="http://2012.igem.org/Team:TU-Delft/Modeling/StructuralModeling#youtube">Prediction of a ligand-binding niche with the human niacin receptor</a></li>
 
<li><a href="http://2012.igem.org/Team:TU-Delft/HumanOutreach">To get public awareness we presented our project to a large audience by participating in several events like Llowlab (~20.000 people!) and the Floriade.</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/HumanOutreach">To get public awareness we presented our project to a large audience by participating in several events like Llowlab (~20.000 people!) and the Floriade.</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/HP">Case study on implementing the snifferometer as diagnostic tool for tuberculosis in developing countries</a></li>
<li><a href="http://2012.igem.org/Team:TU-Delft/HP">Case study on implementing the snifferometer as diagnostic tool for tuberculosis in developing countries</a></li>

Revision as of 00:31, 27 October 2012

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TUDelft -Leiden iGEM 2012
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Snifferomyces
Snifferomyces is a modular system, used in the detection of volatile compounds. It has in the membrane a G-protein–coupled receptor that can bind to a specific signal, once bound it then switches on a signaling machinery which transmits this information over the plasma membrane and through the cell to produce a Quantitative response in the form of fluorescence. Using the Snifferomyces, our aim is to develop a universal olfactory system which allows scientists to introduce olfactory receptors in yeast with minimal effort.
G-protein–coupled receptors (GPCRs) are one of the most important classes of proteins in living organisms that allows transmission of a wide variety of signals over the cell membrane, between cells and over long distances in the human body, thus acting as both the gatekeepers and molecular messengers of the cell. The importance of these receptors is emphasized by the Nobel prize awarded in 2004 for the discoveries of "odorant receptors and the organization of the olfactory system" and in 2012 for "studies of G-protein–coupled receptors".




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