Team:Northwestern/Project

From 2012.igem.org

Revision as of 01:57, 5 September 2012 by Purpleyuan (Talk | contribs)

Phytase Probiotic

[abstract goes here]

Purpose

Our team focused on ameliorating nutrient deficiencies in developing countries. The three main nutrient deficiency disorders listed by the World Health Organization are vitamin A deficiency (VAD), iodine deficiency disorder (IDD) and iron deficiency anemia (IDA). We chose to focus on iron deficiency anemia, which is "the most common and widespread nutritional disorder in the world."

Research has been done in low-income countries to demonstrate that iron deficiency is not a result a lack of iron in the diet, but rather a lack of bioavailability of the iron within the diet. The lack of bioavailability is due to phytate chelating the iron into a state that the body cannot absorb. Phytate (or phytic acid) is the principal form of storage of phosphorous in many plant tissues.

Phytase is an enzyme produced by bacteria and fungi that breaks down phytic acid. We plan on producing a probiotic that will release phytase into the body, thus increasing the bioavailability of iron.

Implementation

Results