Team:Nanjing China Bio/outreach

From 2012.igem.org

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  Community Outreach<br>
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Introduce the concept of synthetic biology, the principle of iGEM and our latest work to the community. 
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   <strong style="font-size:16px;">Would any of your project ideas raise safety issues in terms of: Researcher safety, Public safety, or Environment safety?</strong><br/>
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   <strong style="font-size:16px;">Lecture in Jinling High School</strong><br>
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For the researcher safety, our members are trained by all the safety regulations before we start the experiments. Based on our experimental design, all facilities in the laboratory are performed in Biosafety Level 2 and the materials we use are E.coli Top 10, Salmonella typhimurium VNP, Melanoma B16F10 and the laboratory mice.  Since the Salmonella Typhimurium VNP is infectious, we take some measures to ensure the safety of our team members when we conduct the experiments with the bacteria.  During all the experiments, all the instructions are posted and the workers are requested to wear the nitrile gloves, lab coats and masks.  Moreover, a room is separated for the experiments and the bacteria are kept in a special place.  Normal safety protocols are observed for experimental procedures.  Except for those normal procedures that the team can deal with on a daily basis, we will also use the ultraviolet light in our experiments, so we arrange different people to do this work to reduce the average time each member contacting with it.  As for the public and environment safety, we always keep the products in the cell cultures to avoid their spread to the outside and check their conditions regularly.  At the same time, we also dispose those products according to the protocols.
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On the afternoon of 18th September, the volunteers of our iGEM team gave a lecture at Jinling High School in downtown Nanjing.  We introduced the basic knowledge of molecular and synthetic biology to the students, and helped them comprehend how to modify Salmonella Typhimurium through molecular experiments to increase their ability of tumor targeting and decrease their toxicity in order to be suitable for clinical treatments.  We later presented iGEM High School Division part which they showed great interest in.  We encouraged them to take part in the division and would like to help them with all our efforts.  After the lecture, we had a great time talking with the students.  They were curious about the biology world and asked many questions related to our work.   
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   <strong style="font-size:16px;">Do any of the new BioBrick parts (or devices) that you made this year raise safety issues?</strong>
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   <strong style="font-size:16px;">Communication with Southeast University (SEU)</strong><br>
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<br/>　　NO, none of the new BioBrick parts we made would raise any significant safety issues since all the genes we use commonly exist in E.coli Top 10 and Salmonella Typhimurium VNP. Although the modified bacteria have some advantages compared with the wild type, their abilities are only enhanced in terms of tumor targeting.  Therefore it's still safe for us to use and manipulate the bacteria.  Given that we always keep the bacteria in the cell cultures, there is no chance for them to contact with the outside so it's harmless for the environment.   
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On 20th September, 3 members of our team went to SEU and had a seminar with students there. They knew our work quite well because we had cooperation with the iGEM team of SEU during the summer vacation.  We mainly introduced some characteristics of bacteria therapy from other normal therapies like high colonization and capability of carrying multiple exogenous genes of bacteria.  During the seminar, they raised many valuable questions and offered many suggestions on our experiment methods.  We further discussed on the safety problems of bacteria therapy and came up with some ideas trying to solve them.   
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     <strong style="font-size:16px;">Is there a local biosafety group, committee, or review board at your <br/>institution?</strong>
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     <strong style="font-size:16px;">Lecture in Nanjing University</strong><br>
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<br/>　　Yes, our team is supported by the Department of Life Science, Nanjing University.  So we are under all the Department's safety regulations.  Evaluating the experiments process in terms of safety, the department always reminds our team to put the safety in priority and arrange some experienced research assistants to help us. 
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On 21st September, we presented our work to the teachers and students of School of Life Science in Nanjing University on Xianlin Campus.  We introduced the advantages for VNP20009, the bacteria we used, to be applied in bacteria treatment and the detailed method to optimize the bacteria, which is to screen auxotrophic strains and transfect anaerobic promoters into the bacteria to enhance their efficiency of tumor targeting and killing cancer cells.  In the end of our lecture, we made our outlook on the future of tumor targeting therapy with bacteria.  The professors gave high praises on our work and offered many constructive comments.  <br/>
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Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions? How could parts, devices and systems be made even safer through biosafety engineering?<br/>
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　　In terms of the safety issues, once the synthetic products have the chance to be commercial products, we should take the harmony between synthetic and natural products into consideration and find an appropriate place for the synthetic products.  Most importantly, we should establish some particular protocols for these products which are created by human using synthetic biology techniques.  <br/>
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Revision as of 14:52, 26 September 2012

南京IGEM
CommunityHome > outreach


Community Outreach
Introduce the concept of synthetic biology, the principle of iGEM and our latest work to the community.


Lecture in Jinling High School
On the afternoon of 18th September, the volunteers of our iGEM team gave a lecture at Jinling High School in downtown Nanjing. We introduced the basic knowledge of molecular and synthetic biology to the students, and helped them comprehend how to modify Salmonella Typhimurium through molecular experiments to increase their ability of tumor targeting and decrease their toxicity in order to be suitable for clinical treatments. We later presented iGEM High School Division part which they showed great interest in. We encouraged them to take part in the division and would like to help them with all our efforts. After the lecture, we had a great time talking with the students. They were curious about the biology world and asked many questions related to our work.



Communication with Southeast University (SEU)
On 20th September, 3 members of our team went to SEU and had a seminar with students there. They knew our work quite well because we had cooperation with the iGEM team of SEU during the summer vacation. We mainly introduced some characteristics of bacteria therapy from other normal therapies like high colonization and capability of carrying multiple exogenous genes of bacteria. During the seminar, they raised many valuable questions and offered many suggestions on our experiment methods. We further discussed on the safety problems of bacteria therapy and came up with some ideas trying to solve them.






Lecture in Nanjing University
On 21st September, we presented our work to the teachers and students of School of Life Science in Nanjing University on Xianlin Campus. We introduced the advantages for VNP20009, the bacteria we used, to be applied in bacteria treatment and the detailed method to optimize the bacteria, which is to screen auxotrophic strains and transfect anaerobic promoters into the bacteria to enhance their efficiency of tumor targeting and killing cancer cells. In the end of our lecture, we made our outlook on the future of tumor targeting therapy with bacteria. The professors gave high praises on our work and offered many constructive comments.

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