Team:NTNU Trondheim/Yeast

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NTNU IS B.A.C.K.
Bacterial Anti-Cancer-Kamikaze

Collaboration with RHiT; Yeast modelling

Contents


Overview

Our part of the collaboration with RHiT was helping them with stochastic modelling of the trigger system for mating in yeast. The full mechanism has been quite well studied, but it is very complicated[1]. In RHiTs model, the final steps of the mechanism is activation of the Ste12 protein by the Fus3 enzyme. To simplify the model, production of Fus3 in the model was described by a sigmoid curve found in experiments[2] with respect to the concentration of alpha pheromone. Inactive Ste12 was quickly activated by the presence of Fus3, so the outcome of active Ste12 followed a similar sigmoid curve, giving the expected switch behaviour.

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