Team:NRP-UEA-Norwich

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== '''NRP UEA iGEM Team 2012 Project Outline''' ==
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The iGEM 2012 team for the Norwich Research Park and University of East Anglia (NRP UEA) are a group of seven biology-based undergraduate students working in the labs within UEA’s BIO building. We have been looking at the role of nitric oxide (NO) in biological systems and are aiming to produce a BioBrick that can sense NO within an environment, report on the levels, and go on to make relevant and desirable changes.  
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Possible applications we see for this include; cancer therapeutics, where NO levels are detected and raised above the level at which it aids angiogenesis and into the levels at which it is toxic to a tumour; and environmental aspects, where the bio-sensor may be attached to bioluminescence in order to report levels of NO in soil for instance.
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<img src="https://static.igem.org/mediawiki/2012/5/5f/NRP1.gif"><a href=https://2012.igem.org/Team:NRP-UEA-Norwich/Project><img src="https://static.igem.org/mediawiki/2012/7/75/NRP2.gif"></a><img src="https://static.igem.org/mediawiki/2012/0/00/NRP3.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Parts"><img src=https://static.igem.org/mediawiki/2012/d/df/NRP4.gif></a><img src="https://static.igem.org/mediawiki/2012/9/96/NRP5.gif">
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<img src="https://static.igem.org/mediawiki/2012/8/8b/NRP6.gif"><img src="https://static.igem.org/mediawiki/2012/d/da/NRP7.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Project"><img src="https://static.igem.org/mediawiki/2012/7/79/NRP8.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Project"><img src="https://static.igem.org/mediawiki/2012/0/09/NRP9.gif"></a><img src="https://static.igem.org/mediawiki/2012/9/94/NRP10.gif">
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<a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Future"><img src="https://static.igem.org/mediawiki/2012/e/e5/NRP11.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Future"><img src="https://static.igem.org/mediawiki/2012/8/86/NRP12.gif"></a><img src="https://static.igem.org/mediawiki/2012/f/fe/NRP13.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Notebook"><img src="https://static.igem.org/mediawiki/2012/3/3b/NRP14.gif"></a><img src="https://static.igem.org/mediawiki/2012/d/d4/NRP15.gif">
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<img src="https://static.igem.org/mediawiki/2012/b/bc/NRP16.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Future"><img src="https://static.igem.org/mediawiki/2012/0/01/NRP17.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Quanticare"><img src="https://static.igem.org/mediawiki/2012/2/2d/NRP18.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Notebook"><img src="https://static.igem.org/mediawiki/2012/e/ee/NRP19.gif"></a><img src="https://static.igem.org/mediawiki/2012/0/0a/NRP20.gif">
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<img src="https://static.igem.org/mediawiki/2012/6/60/NRP21.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Future"><img src="https://static.igem.org/mediawiki/2012/1/13/NRP22.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Quanticare"><img src="https://static.igem.org/mediawiki/2012/b/bb/NRP23.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Notebook"><img src="https://static.igem.org/mediawiki/2012/b/b4/NRP24.gif"></a><img src="https://static.igem.org/mediawiki/2012/6/6c/NRP25.gif">
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<img src="https://static.igem.org/mediawiki/2012/1/1d/NRP29.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Human%20Outreach"><img src="https://static.igem.org/mediawiki/2012/d/d3/NRP30.gif"></a><img src="https://static.igem.org/mediawiki/2012/f/f1/NRP31.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Team"><img src="https://static.igem.org/mediawiki/2012/5/52/NRP32.gif"></a><img src="https://static.igem.org/mediawiki/2012/6/6b/NRP33.gif">
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<img src="https://static.igem.org/mediawiki/2012/7/78/NRP34.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Human%20Outreach"><img src="https://static.igem.org/mediawiki/2012/b/bb/NRP35.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Safety"><img src="https://static.igem.org/mediawiki/2012/b/b4/NRP36.gif"></a><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Safety"><img src="https://static.igem.org/mediawiki/2012/1/14/NRP37.gif"></a><img src="https://static.igem.org/mediawiki/2012/6/6c/NRP38.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Team"><img src="https://static.igem.org/mediawiki/2012/5/50/NRP39.gif"></a><img src="https://static.igem.org/mediawiki/2012/5/55/NRP40.gif">
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<img src="https://static.igem.org/mediawiki/2012/b/b5/NRP41.gif"><a href="https://2012.igem.org/Team:NRP-UEA-Norwich/Safety"><img src="https://static.igem.org/mediawiki/2012/4/4b/NRP42.gif"></a><img src="https://static.igem.org/mediawiki/2012/4/4d/NRP43.gif"><img src="https://static.igem.org/mediawiki/2012/7/70/NRP44.png">
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<a href="http://www.norwichresearchpark.com/home.aspx"><img src="https://static.igem.org/mediawiki/2012/d/dc/NRPF1.png"></a><img src="https://static.igem.org/mediawiki/2012/0/0c/NRPF2.png"><a href="https://igem.org/Main_Page"><img src="https://static.igem.org/mediawiki/2012/7/7e/NRPF3.png"></a><img src="https://static.igem.org/mediawiki/2012/d/d8/NRPF4.png"><a href="http://www.uea.ac.uk/"><img src="https://static.igem.org/mediawiki/2012/a/a1/NRPF5.png"></a>
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Our first BioBrick will be a hybrid bacterial and mammalian promoter (using PyeaR and NS2E9 elements) which will detect NO levels. We aim to use a chassis of ''Escherichia coli'' in order to test our BioBrick before investigating its competency within a Salmonella chassis for future applications within a medical system. We also aim to characterise BioBricks produced by previous iGEM teams, especially those involved with sensing physiologically-relevant molecules and reporting with fluorescence or bioluminescence.
 
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We have also looked at various aspects of human outreach and plan to undertake a programme of Synthetic Biology public awareness as well as employing various methods to make our project accessible to those interested outside of the team.
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Latest revision as of 00:57, 27 September 2012

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