Team:MIT/Motivation
From 2012.igem.org
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Qian and Winfree (<i>Science</i> 2011) utilized DNA computation to create AND and OR logic gates <i>in vitro</i>. They constructed a sophisticated binary square root circuit using these gates: | Qian and Winfree (<i>Science</i> 2011) utilized DNA computation to create AND and OR logic gates <i>in vitro</i>. They constructed a sophisticated binary square root circuit using these gates: | ||
- | < | + | <center><img src="http://2012.igem.org/File:MIT_Curly_strands_square_root_circuit.png" width=570/></center> |
+ | |||
+ | Each of these: | ||
+ | <curly strand 1> <curly strand 2> | ||
+ | undergoes the same <b>toehold-mediated strand displacement reaction</b>. These reactions are fully modular and can be scaled to circuits of any degree of sophistication. | ||
+ | |||
+ | <h3>Motivation for Bringing Strand Displacement to Mammalian Synthetic Biology</h3> | ||
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Revision as of 02:14, 27 October 2012
Background and Motivation
In the near future, biological circuits will be much more modular and sophisticated than they are now, with a ten-fold smaller nucleotide footprint.The Enabling Technology: Toehold-Mediated Strand Displacement

Background
Qian and Winfree (Science 2011) utilized DNA computation to create AND and OR logic gates in vitro. They constructed a sophisticated binary square root circuit using these gates: