Team:Lyon-INSA/results

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Our solution is based on engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (<strong>KILL</strong>) and protecting the cleaned surfaces by either a surfactant coating (<strong>COAT</strong> option), or by establishment of a positive biofilm (<strong> STICK </strong> option).<br/>
Our solution is based on engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (<strong>KILL</strong>) and protecting the cleaned surfaces by either a surfactant coating (<strong>COAT</strong> option), or by establishment of a positive biofilm (<strong> STICK </strong> option).<br/>
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This tunneling activity of <i>Bacillus subtilis</i> swimmer cells enable to :
This tunneling activity of <i>Bacillus subtilis</i> swimmer cells enable to :
<li>Facilitate the delivery of the active substances within the biofilm</li><br/>
<li>Facilitate the delivery of the active substances within the biofilm</li><br/>

Revision as of 19:14, 26 October 2012

Context and Objectives



Biofilms are responsible for billions of dollars in production losses and treatment costs in the industry every year. Indeed biofilms involve :

  • Food spoilage or poisoning in the food industry
  • Pathogens' persistence and dispersal in health industry
  • Corrosion and diameter reduction of pipelines

    Assuming that the environment is over-saturated with harmful chemicals such as biocides, whose long-term health effects still have to be elucidated, there is a great need for novel solutions to reduce detrimental biofilm effects.
    Thus, we develop a new generation of solution against biofilms in industry, which allows to reduce :

  • The use of harmful chemical reagents in cleaning processes
  • The cleaning costs for industrialists





  • Click on the title to show/hide the text.

    PROJECT STRATEGY



    Our solution is based on engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (KILL) and protecting the cleaned surfaces by either a surfactant coating (COAT option), or by establishment of a positive biofilm ( STICK option).




    This tunneling activity of Bacillus subtilis swimmer cells enable to :
  • Facilitate the delivery of the active substances within the biofilm

  • Destroy the inacessible biofilms in pipes

  • Bacillus strains are:
    • non pathogenic
    • do not cause equipment deteroriation by corrosion


    • This biocide-alternative strategy provides an money-saving and environementally friendly solution for the control of unwanted biofilm

    KILL : DESTROY BIOFILM


    LYSOSTAPHIN part BBa_K802000





    DISPERSIN part BBa_K802001



    COMBINED EFFECT


    COAT or STICK : AVOID NEW BIOFILM FORMATION


    SURFACTIN + BIOFILM part BBa_K802009



    AVOID NEW BIOFILM FORMATION

    NEW RESULTS



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