Team:Groningen/Notebook/Modeling 8June2012

From 2012.igem.org

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There are clear goals for the FBA analysis:
There are clear goals for the FBA analysis:
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1. Create a quantifiable relationship between the concentration of volatiles in the medium and the lycopene concentration.
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1. Create a quantifiable relationship between the concentration of volatiles in the medium and the lycopene concentration.
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2. Create a quantifiable relationship between the concentration of volatiles in the medium and gene expression.
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2. Create a quantifiable relationship between the concentration of volatiles in the medium and gene expression.
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Is this feasible within our timeframe? The article below draws some doubt. If b. subtilis can so quickly adapt to the environment, then the FBA is only valid for very short timesteps, hence requiring a dynamic model.
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Is this feasible within our timeframe? This <A HREF="http://www.sciencemag.org/content/335/6072/1099.abstract"><FONT COLOR=#ff6700>article</FONT></A>
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draws some doubt. If <i>B. subtilis</i> can so quickly adapt to the environment,
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then the FBA is only valid for very short timesteps, hence requiring a dynamic model.
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"Global Network Reorganization during Dynamic Adaptations of Bacillus subtilis Metabolism" http://www.sciencemag.org/content/335/6072/1099.full
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<A HREF="http://2012.igem.org/Team:Groningen/Notebook"><FONT COLOR=#ff6700>Back to notebook</FONT></A>
<A HREF="http://2012.igem.org/Team:Groningen/Notebook"><FONT COLOR=#ff6700>Back to notebook</FONT></A>
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Latest revision as of 14:27, 26 September 2012







There are clear goals for the FBA analysis:
1. Create a quantifiable relationship between the concentration of volatiles in the medium and the lycopene concentration.
2. Create a quantifiable relationship between the concentration of volatiles in the medium and gene expression.

Is this feasible within our timeframe? This article draws some doubt. If B. subtilis can so quickly adapt to the environment, then the FBA is only valid for very short timesteps, hence requiring a dynamic model.

Back to notebook