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| - | {{Template:Team:Freiburg}}
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| - | <html>
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| - | <head>
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| - | <!-- Timeline script adapted from http://www.csslab.cl/2011/08/18/jquery-timelinr/. Thanks!! -->
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| - | <meta http-equiv="Content-Type" content="text/html; charset=utf-8"/>
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| - | <link rel="stylesheet" href="
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| - | http://omnibus.uni-freiburg.de/~lb125/css/style.css" type="text/css" media="screen" />
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| - | <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.6.2/jquery.min.js" type="text/javascript"></script>
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| - | <script src="http://omnibus.uni-freiburg.de/~lb125/js/jquery.timelinr-0.9.51.js" type="text/javascript"></script>
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| - | <script type="text/javascript">
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| - | $(function(){
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| - | $().timelinr({
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| - | orientation: 'horizontal',
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| - | containerDiv: '#timeline',
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| - | datesDiv: '#dates',
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| - | datesSelectedClass: 'selected',
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| - | datesSpeed: 'normal',
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| - | issuesDiv : '#issues',
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| - | issuesSelectedClass: 'selected',
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| - | issuesSpeed: 'fast',
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| - | issuesTransparency: 0.2,
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| - | issuesTransparencySpeed: 500,
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| - | prevButton: '#prev',
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| - | nextButton: '#next',
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| - | arrowKeys: 'false',
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| - | <style type="text/css">
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| - | #ip_quote
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| - | z-index: -1;
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| - | width:75%;
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| - | color:#C22227;
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| - | font-size:140%;
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| - | text-align:justify;
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| - | </head>
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| - | </html>
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| - | <html>
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| - | <!-- BEGIN TIMELINE WHITEBOX HERE -->
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| - | <div name="talhistory">
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| - | <div id="timeline" style="z-index: -1">
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| - | <ul id="dates">
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| - | <li><a href="#" class="dateobject">2009</a></li>
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| - | <li><a href="#" class="dateobject">2010</a></li>
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| - | <li><a href="#" class="dateobject">02/11</a></li>
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| - | <li><a href="#" class="dateobject">10/11</a></li>
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| - | <li><a href="#" class="dateobject">12/11</a></li>
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| - | <li><a href="#" class="dateobject">02/12</a></li>
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| - | <li><a href="#" class="dateobject">04/12</a></li>
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| - | <li><a href="#" class="dateobject">iGEM'12</a></li>
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| - | </ul>
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| - | <div id="grad_left" style="z-index: -1"></div>
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| - | <div id="grad_right" style="z-index: -1"></div>
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| - | <a href="#" id="next">+</a>
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| - | <a href="#" id="prev">-</a>
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| - | <ul id="issues">
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| - | <li id="#2009">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/10_09.png" width="256" height="170" />
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| - |
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| - | <div class="issuedate">October 2009</div>
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| - | <p>Two research groups publish the TAL Effector codes in the same issue of Science: Amino acid 12 and 13 of every DNA binding module specifically binds to one nucleotide</p>
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| - | </li>
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| - | <li id="#2010">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/10_10.png" width="256" height="200" />
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| - | <div class="issuedate">October 2010</div>
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| - | <p>Voytas Lab develops TALENs. These fusion proteins of FokI and a TAL protein cut as dimers and allow researchers to cut virtually anywhere in the genome. Since double strand breaks increase efficiency of homologous recombination, TALENS are a powerful tool for genetic engineering and gene therapy</p>
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| - | </li>
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| - | <li id="#02/2011">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/02_11.png" width="256" height="256" />
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| - | <div class="issuedate">February 2011</div>
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| - | <p>Based on an exclusive licensing agreement with the University of Minnasota, Cellectis bioresearch launches its TAL effector product line. One TALEN pair currently costs 5000 Euro (6454 US$, 26.10.12).</p>
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| - | <li id="#10/2011">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/10_11.png" width="210" height="256" />
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| - | <div class="issuedate">October 2011</div>
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| - | <p>The iGEM team from Harvard University employed fancy and expensive techniques to find up to 15 new zinc fingers (each of which binds to 3 bp). There has to be a better way…</p>
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| - | </li>
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| - | <li id="#12/2011">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/12_11.png" width="210" height="256" />
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| - | <div class="issuedate">December 2011</div>
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| - | <p>Nature chooses TALENs as the 2011 Method of the year.</p>
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| - | </li>
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| - | <li id="#02/2012">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/02_12.png" width="256" height="256" />
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| - | <div class="issuedate">February 2012</div>
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| - | <p>The first two crystal structures of TALE modules bound to DNA published in the same issue of Science. The protein literally wraps itself around the DNA double helix and forms these beautiful symmetric shapes.</p>
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| - | </li>
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| - | <li id="#04/2012">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/04_12.png" width="256" height="256" />
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| - | <div class="issuedate">April 2012</div>
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| - | <p>Joung lab publishes FLASH assembly in Nature Biotechnology. This first automatable TAL assembly platform facilitates assembly of 96 TAL DNA fragments in less than a day using a pipeting robot.</p>
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| - | </li>
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| - | <li id="freiGEM'12">
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| - | <img src="http://omnibus.uni-freiburg.de/~lb125/10_12.png" width="200" height="130" />
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| - | <div class="issuedate">October 2012</div>
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| - | <p>The Freiburg iGEM team makes TALE technology available to everyone by introducing the GATE assembly kit. For TALEs targeting 14 bp, this platform is currently the fastest, cheapest and easiest method in the world.</p>
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| - | </li>
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| - | </ul>
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| - | </div>
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| - | </div>
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| - | <!-- END TIMELINE WHITEBOX HERE -->
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