Team:Exeter

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       <p><a href="http://www.wellcome.ac.uk/index.htm"><img src="https://static.igem.org/mediawiki/igem.org/0/03/Exe2012Wellcometrustlogo.png" width="200px" alt="Find out more about the Wellcome Trust" title="" /></a>
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       <p><a href="http://www.wellcome.ac.uk/index.htm"><img src="https://static.igem.org/mediawiki/igem.org/0/03/Exe2012Wellcometrustlogo.png" width="150px" alt="Find out more about the Wellcome  
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      Trust" title="Find out more about the Wellcome Trust" /></a>
       </p>
       </p>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
       <p><a href="http://www.exeter.ac.uk/alumnisupporters/supporting/how/makeagift/annualfund/"><img src="https://static.igem.org/mediawiki/igem.org/f/fc/Exe2012Annualfundlogo.png" align="middle"
       <p><a href="http://www.exeter.ac.uk/alumnisupporters/supporting/how/makeagift/annualfund/"><img src="https://static.igem.org/mediawiki/igem.org/f/fc/Exe2012Annualfundlogo.png" align="middle"
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       width="200px" alt="Find out how to donate to the Exeter University Annual Fund" title="" /></a>
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       <p>&nbsp;</p>
       <p>&nbsp;</p>
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      <p><a href="http://www.nuffieldfoundation.org/"><img src="https://static.igem.org/mediawiki/igem.org/b/be/Nuffield-logo-full-colour-.gif" align="middle"
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       <p><font face="DokChampa" color="#1d1d1b" size="2"><b>With Kind Contribution From:</b></font>
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      <font face="DokChampa" color="#1d1d1b" size="2"><li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=murray_grant" style="color:#1d1d1b">Professor Murray Grant
 
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      </a></li><li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=ken_haynes" style="color:#1d1d1b">Professor Ken Haynes</a></li><li><a href=
 
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      "http://biosciences.exeter.ac.uk/staff/index.php?web_id=Rob_Beardmore" style="color:#1d1d1b">Professor Robert Beardmore</a></li>
 
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      <p>&nbsp;</p>
 
       <p>&nbsp;</p>
       <p>&nbsp;</p>
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      <p><a href="http://www.dna20.com/"><img src="https://static.igem.org/mediawiki/2012/4/42/Exe2012Dna2.png" align="middle"
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      </p>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
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      <p><a href="http://eu.idtdna.com/site"><img src="https://static.igem.org/mediawiki/2012/c/cc/Exe2012IDTLogo2010.png" align="middle"
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      width="150px" alt="Visit the DNA 2.0 Shop" title="Visit the DNA 2.0 Shop" /></a>
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      </p>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
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    </div>
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      <p><font face="Verdana" color="#1d1d1b" size="2"><b>Additional Generous Funding From:</b></font>
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      </p>
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      <font face="Verdana" color="#1d1d1b" size="2">
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=Rob_Beardmore" style="color:#1d1d1b">Prof. Rob Beardmore</a></li>     
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=murray_grant" style="color:#1d1d1b">Prof. Murray Grant</a></li>
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=ken_haynes" style="color:#1d1d1b">Prof. Ken Haynes</a></li>
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=john_love" style="color:#1d1d1b">Prof. John Love</a></li>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
       <p>&nbsp;</p>
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      <font color="#57B947" size="+1" face="Verdana">
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      <a href="https://2012.igem.org/Team:Exeter/Concept" style="color:#57B947">e-candi: The Story</a>
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        &nbsp;&nbsp;|&nbsp;&nbsp;
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      <a href="https://2012.igem.org/Team:Exeter/Results" style="color:#57B947">Results at a Glance</a>
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        &nbsp;&nbsp;|&nbsp;&nbsp;
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      <a href="http://glycoweb.com/" style="color:#57B947" target="_blank">Build Your Own Polysaccharide</a>
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      <p>The iterative design cycle allows scientists and engineers to continually adapt and take advantage of
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      what has already been learnt. This project, e-candi, investigates whether synthetic biology can provide a platform technology to revolutionise polysaccharide research, allowing rapid biosynthesis of designer polysaccharides and the implementation of such a design cycle.</p>
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    <br>
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      <font face="DokChampa" color="#1d1d1b" size="+2"><b>Project Abstract:</b>
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      <p>Our aim is to design a system for the synthesis of bespoke polysaccharides in <em>Escherichia  coli</em>. We intend to show that a future where designer polysaccharides
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    <p><u>Website Designed and Built by: Ryan Edginton, James Lynch & Alex Clowsley</u> &nbsp;&nbsp;|&nbsp;&nbsp;
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      can be created on demand is not only  feasible, but in fact highly achievable.</p>
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    <a href="https://igem.org/Team.cgi?id=764" style="color:#57B947" target="_blank"><u>Contact Us</u></a> &nbsp;&nbsp;|&nbsp;&nbsp;
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      <p>The ability to tailor-make polysaccharides would lead to revolutionary technological developments in many fields, such as medicine (rapid vaccine production) and the
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    <a href="https://2012.igem.org/Team:Exeter/site_map" style="color:#57B947"><u>Site Map</u></a></p>
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      industrial sector (production of novel materials) to name but two.</p>
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      <p>We are using several approaches to demonstrate how this is possible. Firstly we want to synthesise useful existing polysaccharides (such as hyaluronan) in the unfamiliar
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      setting of <em>E. coli</em>. Secondly, to achieve the synthetic  polysaccharide, we will implement the addition of glycosyltransferases  from different <em>E. Coli</em> to
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      our own sample strain, both individually for characterisation and in an operon, allowing polysaccharide production via the well documented Wzy-dependent system.
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      As well as implementing a full operon for each polysaccharide, we plan to construct an engineered plasmid. This will  allow controlled expression of different enzymes,
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      induced through different promoters to enable choice without repeated genetic transformations..</p>
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      <p>The complementary dry lab work provides a basis for that of the wet lab and the principle of in vivo synthesis of novel polysaccharides. The generation of a database of
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      enzymes with a user-friendly interface will aim to assist polysaccharide design, leading to a future where any polysaccharide is possible. We are also investigating kinetic
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      models to flag up conflicts in enzyme activities to optimise polysaccharide construction pathways, and we plan to use TinkerCell to explore possible methods of controlling
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      multiple enzyme expression and enzyme expression levels.</p>
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Latest revision as of 23:41, 26 September 2012

ExiGEM2012 Homepage

Find out more about the Wellcome Trust

 

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Visit the DNA 2.0 Shop

 

Visit the DNA 2.0 Shop

 

Additional Generous Funding From:

  • Prof. Rob Beardmore
  • Prof. Murray Grant
  • Prof. Ken Haynes
  • Prof. John Love

    •  

     

     

     

     

     

     

     

     
    		e-candi: The Story   |   Results at a Glance   |   Build Your Own Polysaccharide

    The iterative design cycle allows scientists and engineers to continually adapt and take advantage of what has already been learnt. This project, e-candi, investigates whether synthetic biology can provide a platform technology to revolutionise polysaccharide research, allowing rapid biosynthesis of designer polysaccharides and the implementation of such a design cycle.
     
    		 

    Website Designed and Built by: Ryan Edginton, James Lynch & Alex Clowsley   |   Contact Us   |   Site Map

    Retrieved from "http://2012.igem.org/Team:Exeter"