Team:Exeter

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      <p><a href="http://www.wellcome.ac.uk/index.htm"><img src="https://static.igem.org/mediawiki/igem.org/0/03/Exe2012Wellcometrustlogo.png" width="150px" alt="Find out more about the Wellcome
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      <p><font face="Verdana" color="#1d1d1b" size="2"><b>Additional Generous Funding From:</b></font>
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      </p>
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      <font face="Verdana" color="#1d1d1b" size="2">
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=Rob_Beardmore" style="color:#1d1d1b">Prof. Rob Beardmore</a></li>     
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=murray_grant" style="color:#1d1d1b">Prof. Murray Grant</a></li>
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=ken_haynes" style="color:#1d1d1b">Prof. Ken Haynes</a></li>
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      <li><a href="http://biosciences.exeter.ac.uk/staff/index.php?web_id=john_love" style="color:#1d1d1b">Prof. John Love</a></li>
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      <p>&nbsp;</p>
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      <a href="https://2012.igem.org/Team:Exeter/Concept" style="color:#57B947">e-candi: The Story</a>
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        &nbsp;&nbsp;|&nbsp;&nbsp;
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      <a href="https://2012.igem.org/Team:Exeter/Results" style="color:#57B947">Results at a Glance</a>
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        &nbsp;&nbsp;|&nbsp;&nbsp;
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      <a href="http://glycoweb.com/" style="color:#57B947" target="_blank">Build Your Own Polysaccharide</a>
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      <p>The iterative design cycle allows scientists and engineers to continually adapt and take advantage of
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      what has already been learnt. This project, e-candi, investigates whether synthetic biology can provide a platform technology to revolutionise polysaccharide research, allowing rapid biosynthesis of designer polysaccharides and the implementation of such a design cycle.</p>
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      <font face="DokChampa" color="#1d1d1b" size="+2"><b>Project Abstract:</b></font>
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    <p>Our aim is to design a system for the synthesis of bespoke polysaccharides in <em>Escherichia  coli</em>. We intend to show that a future where designer polysaccharides can be created on demand is not only  feasible, but in fact highly achievable.</p>
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      <p>The ability to tailor-make polysaccharides would lead to revolutionary technological developments in many fields, such as medicine (rapid vaccine production) and the industrial sector (production of novel materials) to name but two.      </p>
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      <p>We are using several approaches to demonstrate how this is possible. Firstly we want to synthesise useful existing polysaccharides (such as hyaluronan) in the unfamiliar setting of <em>E. coli</em>. Secondly, to achieve the synthetic  polysaccharide, we will implement the addition of glycosyltransferases  from different <em>E. Coli</em> to our own sample strain, both individually for characterisation and in an operon, allowing polysaccharide production via the well documented Wzy-dependent system.
 
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      As well as implementing a full operon for each polysaccharide, we plan to construct an engineered plasmid. This will  allow controlled expression of different enzymes, induced through different promoters to enable choice without repeated genetic transformations..</p>
 
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      <p>The complementary dry lab work provides a basis for that of the wet lab and the principle of in vivo synthesis of novel polysaccharides. The generation of a database of enzymes with a user-friendly interface will aim to assist polysaccharide design, leading to a future where any polysaccharide is possible. We are also investigating kinetic models to flag up conflicts in enzyme activities to optimise polysaccharide construction pathways, and we plan to use TinkerCell to explore possible methods of controlling multiple enzyme expression and enzyme expression levels.</p></font>
 
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    <p><u>Website Designed and Built by: Ryan Edginton, James Lynch & Alex Clowsley</u> &nbsp;&nbsp;|&nbsp;&nbsp;
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    <a href="https://igem.org/Team.cgi?id=764" style="color:#57B947" target="_blank"><u>Contact Us</u></a> &nbsp;&nbsp;|&nbsp;&nbsp;
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    <a href="https://2012.igem.org/Team:Exeter/site_map" style="color:#57B947"><u>Site Map</u></a></p>
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Latest revision as of 23:41, 26 September 2012

ExiGEM2012 Homepage

Find out more about the Wellcome Trust

 

Find out how to donate to the Exeter University Annual Fund

 

Find out about the Nuffield Foundation

 

Visit the DNA 2.0 Shop

 

Visit the DNA 2.0 Shop

 

Additional Generous Funding From:

  • Prof. Rob Beardmore
  • Prof. Murray Grant
  • Prof. Ken Haynes
  • Prof. John Love

    •  

     

     

     

     

     

     

     

     
    		e-candi: The Story   |   Results at a Glance   |   Build Your Own Polysaccharide

    The iterative design cycle allows scientists and engineers to continually adapt and take advantage of what has already been learnt. This project, e-candi, investigates whether synthetic biology can provide a platform technology to revolutionise polysaccharide research, allowing rapid biosynthesis of designer polysaccharides and the implementation of such a design cycle.
     
    		 

    Website Designed and Built by: Ryan Edginton, James Lynch & Alex Clowsley   |   Contact Us   |   Site Map

    Retrieved from "http://2012.igem.org/Team:Exeter"