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A Flux-Variability Analysis for Optimization

Background What is Metabolic Flux Analysis? Metabolic Flux balance analysis (FBA) is an application of linear programming to metabolic network that uses the stoichiometric coefficients for each reaction in the system as the set of constraints for the optimization. Simply, it is a mathematical method for analyzing metabolism. This analysis requires the Steady State Assumption, which is, in chemistry, a steady state is a situation in which all state variables are constant in spite of ongoing processes that strive to change them. In addition, Flux Variability Analysis (FVA) is an extension of Flux balance analysis that is able to calculate the full range of numerical values for each reaction flux within the network.